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| | N-(2-broMophenyl)-N-Methyl-MethanesulfonaMide Basic information |
| | N-(2-broMophenyl)-N-Methyl-MethanesulfonaMide Chemical Properties |
| Boiling point | 333.6±44.0 °C(Predicted) | | density | 1.604±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | -3.03±0.50(Predicted) | | Appearance | White to off-white Solid |
| | N-(2-broMophenyl)-N-Methyl-MethanesulfonaMide Usage And Synthesis |
| Synthesis | GENERAL STEPS: To a suspension of N-(2-bromophenyl)methane sulfonamide (5.01 g, 20.0 mmol) and cesium carbonate (7.2 g, 22 mmol) in acetonitrile (20 mL) was added iodomethane (1.4 mL, 22 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane (30 mL), filtered through a diatomaceous earth plug and the filtrate was concentrated under reduced pressure. N-(2-bromophenyl)-N-methylmethanesulfonamide was obtained as a light orange solid (5.22 g, 98% yield). The product was characterized by 1H NMR (400 MHz, CDCl3, δ, ppm): 7.65 (d, J = 8.0 Hz, 1H), 7.50 (d, J = 7.9 Hz, 1H), 7.37 (t, J = 7.4 Hz, 1H), 7.23 (t, J = 8.2 Hz, 1H), 3.29 (s, 3H), 3.06 (s, 3H). Mass spectrometry (MS) analysis showed m/z = 286,288 (MH+). | | References | [1] Patent: WO2010/141796, 2010, A2. Location in patent: Page/Page column 276
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0104; 0110
[3] Tetrahedron, 2014, vol. 70, # 49, p. 9359 - 9365
[4] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0372-0373 |
| | N-(2-broMophenyl)-N-Methyl-MethanesulfonaMide Preparation Products And Raw materials |
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