2-BroMo-4-Methyl-1-nitro-benzene manufacturers
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| | 2-BroMo-4-Methyl-1-nitro-benzene Basic information |
| | 2-BroMo-4-Methyl-1-nitro-benzene Chemical Properties |
| Melting point | 37.8°C | | Boiling point | 269°C (rough estimate) | | density | 1.6841 (rough estimate) | | refractive index | 1.6120 (estimate) | | storage temp. | Sealed in dry,Room Temperature |
| | 2-BroMo-4-Methyl-1-nitro-benzene Usage And Synthesis |
| Uses | 3-Bromo-4-nitrotoluene is a compound involved in the synthesis of novel phenylalanine-based amino acids as kainate receptor ligands. | | Synthesis | General procedure for the synthesis of 2-bromo-4-methyl-1-nitrobenzene from 2-bromo-4-methylaniline: 77% 3-chloroperoxybenzoic acid (150 mmol, 33.62 g) was added to a solution of 2-bromo-4-methylaniline (30 mmol, 5.56 g) in toluene (100 mL), and the reaction mixture was heated and refluxed for 6 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was washed sequentially with 10% sodium hydroxide solution (2 x 100 mL) and saturated saline (100 mL), and the organic phase was dried with anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure and the resulting residue was purified by fast column chromatography. | | References | [1] Journal of the American Chemical Society, 2005, vol. 127, # 13, p. 4609 - 4624
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 22, p. 5568 - 5572
[3] Collection of Czechoslovak Chemical Communications, 1967, vol. 32, # 1, p. 382 - 397
[4] Journal of medicinal chemistry, 1971, vol. 14, # 11, p. 1113 - 1115
[5] Tetrahedron Letters, 1992, vol. 33, # 33, p. 4799 - 4802 |
| | 2-BroMo-4-Methyl-1-nitro-benzene Preparation Products And Raw materials |
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