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| | Methyl 2-aMino-6-hydroxybenzoate Basic information |
| Product Name: | Methyl 2-aMino-6-hydroxybenzoate | | Synonyms: | Methyl 2-aMino-6-hydroxybenzoate;2-AMino-6-hydroxy-benzoic acid Methyl ester;Prucalopride Impurity45;Benzoic acid, 2-amino-6-hydroxy-, methyl ester;Prucalopride Succinate iMpurit 45;methyl 2-2-amino-6-6-hydroxybenzoate - [AC78555] | | CAS: | 64241-01-6 | | MF: | C8H9NO3 | | MW: | 167.16 | | EINECS: | | | Product Categories: | | | Mol File: | 64241-01-6.mol |  |
| | Methyl 2-aMino-6-hydroxybenzoate Chemical Properties |
| Melting point | 147-148 °C | | Boiling point | 278.3±20.0 °C(Predicted) | | density | 1.305±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 9.81±0.10(Predicted) | | Appearance | White to light yellow Solid |
| | Methyl 2-aMino-6-hydroxybenzoate Usage And Synthesis |
| Synthesis | The general procedure for synthesizing methyl 2-amino-6-hydroxybenzoate from indirubic anhydride is as follows:Example 386B Synthesis of methyl 2-amino-6-hydroxybenzoate. Example 386A (1.0 g, 5.6 mmol) was mixed with methanol (40 mL) and heated to reflux for 6 hours. Upon completion of the reaction, the mixture was concentrated and purified by silica gel column chromatography using a hexane solution of 30% ethyl acetate as eluent to give 0.81 g of the target product, methyl 2-amino-6-hydroxybenzoate, in 86.6% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 3.88 (s, 3H), 5.95 (d, 1H), 6.20 (d, 1H), 6.34 (s, 1H), 7.02 (t, 1H), 10.88 (s, 1H); the mass spectrum (DCI/NH3) showed m/e 168 (M + H)+. | | References | [1] Patent: US2004/167128, 2004, A1. Location in patent: Page 76 |
| | Methyl 2-aMino-6-hydroxybenzoate Preparation Products And Raw materials |
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