ON 146040 manufacturers
- ON 146040
-
- $41.00 / 1mg
-
2025-10-27
- CAS:1404231-34-0
- Min. Order:
- Purity: 99.89%
- Supply Ability: 10g
- ON 146040
-
- $41.00 / 1mg
-
2025-10-26
- CAS:1404231-34-0
- Min. Order:
- Purity: 99.89%
- Supply Ability: 10g
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| | ON 146040 Basic information |
| Product Name: | ON 146040 | | Synonyms: | ON 146040;(7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one;5H-Pyrimido[4,5-b][1,4]thiazin-6(7H)-one, 2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-[(4-nitrophenyl)methylene]-;2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-7-(4-nitrobenzylidene)-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one;ON 146040, 10 mM in DMSO | | CAS: | 1404231-34-0 | | MF: | C24H23N7O3S | | MW: | 489.55 | | EINECS: | | | Product Categories: | | | Mol File: | 1404231-34-0.mol |  |
| | ON 146040 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | color | Brown to reddish brown |
| | ON 146040 Usage And Synthesis |
| Uses | ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM). | | IC 50 | PI3Kα: 14 nM (IC50); PI3Kδ: 20 nM (IC50); PI3Kγ: 1 μM (IC50); PI3Kβ: 3 μM (IC50) | | References | [1] Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL. |
| | ON 146040 Preparation Products And Raw materials |
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