ON 146040 NEW
| Price | $41 | $103 | $167 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: ON 146040 | CAS No.: 1404231-34-0 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | ON 146040 |
| Description | ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively. |
| In vitro | ON 146040 inhibits Abl1 and several mutant versions of this kinase with IC50 < 150 nM. ON 146040 is highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1000 nM range. ON 146040 downregulates the phosphorylation of STAT3 and STAT5 in leukemia and myeloma cells[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.9 mg/mL (10.01 mM), Sonication is recommended. |
| Keywords | ZINC-211117138 | ZINC 211117138 | PI3Kδ | PI3Kγ | PI3Kβ | PI3Kα | ON-146040 | ON146040 | ON 146040 | BcrAbl | Abl1 |
| Inhibitors Related | Myricetin | Erucic acid | Sapanisertib | GNF-5 | 3-Methyladenine | Duvelisib (R enantiomer) hydrochloride | Isoprenaline hydrochloride | Imatinib | Quercetin | Inavolisib | Quercetin Dihydrate | Apilimod |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Hematonosis Compound Library | Anti-Breast Cancer Compound Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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