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| | PHA-767491 (hydrochloride) Basic information |
| Product Name: | PHA-767491 (hydrochloride) | | Synonyms: | CAY-10572 HYDROCHLORIDE;2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride;PHA-767491A hydrochloride;CAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor;PHA-767491 hydrochloride, 10 mM in DMSO;PHA-767491 HCl ，S2742 | | CAS: | 942425-68-5 | | MF: | C12H12ClN3O | | MW: | 249.7 | | EINECS: | | | Product Categories: | | | Mol File: | 942425-68-5.mol |  |
| | PHA-767491 (hydrochloride) Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO:20.0(Max Conc. mg/mL);80.1(Max Conc. mM) | | form | A crystalline solid | | color | Light yellow to yellow |
| | PHA-767491 (hydrochloride) Usage And Synthesis |
| Uses | PHA 767491 Hydrochloride (cas# 942425-68-5) is a useful research chemical used in the synthesis of heteroaryl-substituted pyrrolopyridinones and analogs as cdc7 kinase inhibitors and potential antitumor agents. | | in vivo | PHA-767491 decreases Chk1 phosphorylation and increases in situ cell apoptosis in tumor tissues sectioned from nude mice HCC xenografts[2]. | | IC 50 | CDK9: 34 nM (IC50); CDK2: 240 nM (IC50); CDK1: 250 nM (IC50); CDK5: 460 nM (IC50); GSK3-β: 220 nM (IC50); Mk2: 470 nM (IC50); Plk1: 980 nM (IC50); Chk2: 1100 nM (IC50) | | storage | Desiccate at RT |
| | PHA-767491 (hydrochloride) Preparation Products And Raw materials |
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