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T&W GROUP |
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021-61551611 13296011611 |
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contact@trustwe.com |
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Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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Puripharm Co., Ltd. |
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| | Bz-Tz-NHS Basic information |
| Product Name: | Bz-Tz-NHS | | Synonyms: | 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate;5-Oxo-5-[[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]amino]pentanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Benzylamino tetrazine N-hydroxysuccinimidyl ester;Benzylaminotetrazine-NHS;Bz-Tz-NHS;2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate;Tetrazine-Ph-NHCO-C3-NHS ester;2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate >=90% | | CAS: | 1244040-64-9 | | MF: | C18H18N6O5 | | MW: | 398.37272 | | EINECS: | | | Product Categories: | | | Mol File: | 1244040-64-9.mol |  |
| | Bz-Tz-NHS Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO : 100 mg/mL (251.02 mM; Need ultrasonic) | | pka | 14.57±0.46(Predicted) | | form | Solid | | color | Pink to red | | InChI | 1S/C18H18N6O5/c25-14(2-1-3-17(28)29-24-15(26)8-9-16(24)27)19-10-12-4-6-13(7-5-12)18-22-20-11-21-23-18/h4-7,11H,1-3,8-10H2,(H,19,25) | | InChIKey | QDUUJWMNSUXICN-UHFFFAOYSA-N | | SMILES | O=C(CCCC(ON1C(CCC1=O)=O)=O)NCC(C=C2)=CC=C2C3=NN=CN=N3 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Bz-Tz-NHS Usage And Synthesis |
| Uses | Succinimidyl ester functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. Succinimidyl ester will react with amines for small molecule, biomolecule or surface modification. Tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications. | | reaction suitability | reaction type: click chemistry
reagent type: linker | | IC 50 | PEGs |
| | Bz-Tz-NHS Preparation Products And Raw materials |
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