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Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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| | Carboxypeptidase G Basic information |
| Product Name: | Carboxypeptidase G | | Synonyms: | GAMMA-GLUTAMYL HYDROLASE;EC 3.4.19.9;carboxypeptidase G from pseudomonas sp. purificat;Hydrolase, gamma-glutamyl;CARBOXYPEPTIDASE G FROM PSEUDOMONAS SP.;γ-glutamyl hydrolase;Native Pseudomonas sp. Carboxypeptidase G;Carboxypeptidase G from Pseudomonas sp. lyophilized powder, >=3 units/mg protein | | CAS: | 9074-87-7 | | MF: | Zn4+8 | | MW: | 261.56 | | EINECS: | 232-978-1 | | Product Categories: | | | Mol File: | 9074-87-7.mol |  |
| | Carboxypeptidase G Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble0.5mg/mL | | form | lyophilized powder | | Water Solubility | H2O: soluble 0.5mg/mL | | Specific Activity | ≥3units/mg protein |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
STOT SE 3 |
| | Carboxypeptidase G Usage And Synthesis |
| Uses | Carboxypeptidase G from Pseudomonas sp., or γ-Glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations. Carboxypeptidase G from Pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via NOcGMP signaling in lung adenocarcinoma cells. | | Biochem/physiol Actions | Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group. Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions. |
| | Carboxypeptidase G Preparation Products And Raw materials |
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