| Company Name: |
Wuhan Chemstan Biotechnology Co., Ltd.
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| Tel: |
027-65317797 15926423062 |
| Email: |
422450190@qq.com |
| Products Intro: |
Product Name:Recombinant Mouse Havcr2/Tim-3 Protein, His Tag
Purity:90% as determined by SDS-PAGE Package:50ug;100ug
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| Company Name: |
Biolab Reagents
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| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
| Products Intro: |
Product Name:TIM-3
Purity:95% SDS-PAGE Package:1mg;100ug
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| Company Name: |
ACROBiosystems
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| Tel: |
13121935750 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
| Products Intro: |
Product Name:TIM-3
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| Product Name: | TIMD3 | | Synonyms: | Mouse TIM-3 elisa kit;T-cell immunoglobulin and mucin domain-containing protein 3;Tim-3 (human): FC (human);HAVcr-2;TIMD3;Recombinant Human HAVCR2 Protein, His Tag;Recombinant Mouse TIM-3/Havcr2 Protein, His Tag;Recombinant Mouse TIM-3/Havcr2 C-fc Protein, Fc Tag | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![TIMD3 Structure]() |
| | TIMD3 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | white | | biological source | human |
| WGK Germany | WGK 2 | | Storage Class | 10 - Combustible liquids |
| | TIMD3 Usage And Synthesis |
| Uses | The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade. |
| | TIMD3 Preparation Products And Raw materials |
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