AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) manufacturers
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| | AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Basic information |
| Product Name: | AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) | | Synonyms: | Amyloid β-peptide (1-40) (rat);Rat aMyloid-beta peptide 1-40;Rat aMyloid-β peptide 1-40;AMyloid b-Protein (1-40) (Mouse, rat);H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH;Amyloid beta-peptide (1-40) (rat);-peptide (1-40) rat;β-Amyloid (1-40), rat | | CAS: | 144409-98-3 | | MF: | C190H291N51O57S | | MW: | 0 | | EINECS: | | | Product Categories: | Alzheimer | | Mol File: | Mol File | ![AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Structure]() |
| | AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Chemical Properties |
| storage temp. | -15°C | | solubility | Soluble to 1 mg/ml in 1% Ammonia | | form | Solid | | color | White to off-white | | Sequence | H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH |
| | AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Usage And Synthesis |
| Uses | β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease[1][2]. | | in vivo | β-Amyloid (1-40) (rat) (1.7 mg; ICV, for 7 d; swiss and C57BL/6 mice) induces the learning and memory deficits in mice[3]. | Animal Model: | Swiss and C57BL/6 mice[3] | | Dosage: | 1.7 mg | | Administration: | Intracerebroventrical injection; for 7 days | | Result: | Presented spatial learning and memory impairments. |
| | storage | Desiccate at -20°C | | References | [1] MacManus A, et, al. Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem. 2000 Feb 18;275(7):4713-8. DOI:10.1074/jbc.275.7.4713
[2] Miguel-Hidalgo JJ, et, al. Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield. Acta Neuropathol. 1998 May;95(5):455-65. DOI:10.1007/s004010050825
[3] Prediger RD, et, al. Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Behav Brain Res. 2007 Feb 27;177(2):205-13. DOI:10.1016/j.bbr.2006.11.032 |
| | AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Preparation Products And Raw materials |
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