| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:GTP 14564;3-Phenyl-1H-benzofuro[3,2-c]pyrazole
CAS:34823-86-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Nanjing Dulai Biotechnology Co., Ltd.
|
| Tel: |
025-84699383-8003;025-846993838003-8003 18013301593;18013301590 |
| Email: |
njduly@126.com |
| Products Intro: |
Product Name:GTP 14564
CAS:34823-86-4
Purity:>=99% Package:100mg
|
| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:GTP 14564
CAS:34823-86-4
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Basic information |
| | 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Chemical Properties |
| Melting point | 222-223 °C | | Boiling point | 459.1±25.0 °C(Predicted) | | density | 1.321±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | 12.72±0.30(Predicted) | | color | Off-white to yellow | | InChI | 1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17) | | InChIKey | DZQLVVLATXPWBK-UHFFFAOYSA-N |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Usage And Synthesis |
| Description | GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 μM for c-Fms, c-Kit, ITD-FLT3 and 1 μM for PDGFRβ). It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases. GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5. | | Uses | GTP 14564 is a class III receptor tyrosine kinase (RTK) inhibitor. | | Definition | ChEBI: 3-phenyl-1H-benzofuro[3,2-c]pyrazole is a member of pyrazoles and a ring assembly. | | Biological Activity | Potent, selective inhibitor of class III receptor tyrosine kinases (IC 50 values are 0.3 μ M for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μ M for PDGFR β ). Displays no selectivity for ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μ M). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukaemic. | | References | [1] KEN MURATA. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).[J]. The Journal of Biological Chemistry, 2003, 278 35: 32892-32898. DOI: 10.1074/jbc.m210405200
[2] Q YAO. Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway[J]. Leukemia, 2005, 19 9: 1605-1612. DOI: 10.1038/sj.leu.2403881 |
| | 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Preparation Products And Raw materials |
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