- Guaiazulene
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- $500.00
-
2026-06-28
- CAS:489-84-9
- Purity: 99%
- Supply Ability: 5000
- Guaiazulene
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- $10.00
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2026-06-26
- CAS:489-84-9
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 1 ton
- Guaiazulene
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-
2026-06-22
- CAS:489-84-9
- Min. Order: 1KG
- Purity: 99.9% up
- Supply Ability: 20 tons
Related articles - Application research of guaiazulene
- Guaiazulene is present in several essential oils of medicinal and aromatic plants. Herein its properities and application rese....
- Sep 9，2025
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| | Guaiazulene Basic information |
| | Guaiazulene Chemical Properties |
| Melting point | 27-29 °C (lit.) | | Boiling point | 153 °C/7 mmHg (lit.) | | density | 0.976 g/mL at 25 °C (lit.) | | refractive index | 1.3166 (estimate) | | Fp | >230 °F | | storage temp. | Sealed in dry,2-8°C | | solubility | Chloroform (Slightly), Methanol (Sparingly) | | form | Low Melting Crystalline Solid | | color | Dark blue | | Water Solubility | Soluble in alcohol, water, 0.1115 mg/L @ 25°C (est). | | Merck | 14,4554 | | BRN | 1365001 | | Cosmetics Ingredients Functions | ANTIMICROBIAL
PERFUMING | | InChI | 1S/C15H18/c1-10(2)13-7-5-11(3)14-8-6-12(4)15(14)9-13/h5-10H,1-4H3 | | InChIKey | FWKQNCXZGNBPFD-UHFFFAOYSA-N | | SMILES | CC(C)c1ccc(C)c2ccc(C)c2c1 | | LogP | 5.590 (est) | | CAS DataBase Reference | 489-84-9(CAS DataBase Reference) | | NIST Chemistry Reference | Azulene, 1,4-dimethyl-7-(1-methylethyl)-(489-84-9) | | EPA Substance Registry System | Azulene, 1,4-dimethyl-7-(1-methylethyl)- (489-84-9) |
| Hazard Codes | Xn | | Risk Statements | 22-20/21/22 | | Safety Statements | 36/37/39-26-22-36 | | WGK Germany | 3 | | RTECS | CO4790000 | | TSCA | TSCA listed | | HS Code | 2902190000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Guaiazulene Usage And Synthesis |
| Chemical Properties | DARK BLUE LOW MELTING CRYSTALLINE SOLID | | Originator | AZ 8,Millet Roux | | Uses | antioxidant, inhibits lipid peroxidation inhibitor, antiinflammatory, hepatoprotectant; LD50(rat) 1550 mg/kg po | | Uses | Guaiazulene can be used as a starting material for the synthesis of:
- Azulene-based dye molecules such as 3-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanoacrylic acid and 5-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanopenta-2,4-dienoic acid.
- Stilbazulenyl nitrone, a second-generation azulenyl nitrone which can be used as a chain-breaking antioxidant.
- Bis-azulenyl based near-infrared fluorescence quencher.
| | Definition | ChEBI: Guaiazulene is a sesquiterpene. It derives from a hydride of a guaiane. | | Manufacturing Process | 10 kg a gum of Guacum officinale was heated with 3-4 kg of sulfur to 130°C.
The heating was slowly continued for 220°C under the nitrogen. The formed
water steam was removed with the nitrogen current. The temperature should
be higher 100°C in order to the water didnt fall into reaction mixture. H2S was
obtained simultaneously the dehydrogenation and removed with water steam.
Hydrogen sulfide was connected in an alkaline trap.
When a H2S discharge stopped, the temperature was decreased to 120°C and
the reaction mixture was distilled in vacuum 1-20 mm. The distillate had deep
blue color and contained 6-7 kg oil with 20% of 7-isopropyl-1,4-
dimethylazulene. It was dissolved in the 5-10 volumes of light petroleum,
shook with sodium hydroxide for removing the sulfur containing substaneces,
washed to neutral. Then petrolem layer was mixed with 10-15 L 62% H2SO4
for removing the by-products, the petroleum layer lost the blue color and the
desired substance was in sulphuric acid layer. The last one was shook with ice
and NaOH. As a result about 7% NaSO4 solution in sulfuric acid was obtained.
It was diluted and azulene gave an emulsion, which was extracted with 10 L
of petrolem and distilled. The 7-isopropyl-1,4-dimethylazulene is distilled at
167°-168°C/12 mm. Yield 10-15%. | | Therapeutic Function | Antiinflammatory | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | Purification Methods | It forms blue-violet plates from EtOH. Also redistil it in vacuo until distillate solidifies. UV has max at 284nm (log 4.6, heptane). The picrate has m 122o(EtOH). [Beilstein 5 III 1677, 5 IV 1751.] |
| | Guaiazulene Preparation Products And Raw materials |
| Raw materials | Sulfur-->Ethanamine, 2,2'-[[2-[3,8-dimethyl-5-(1-methylethyl)-1-azulenyl]ethenylidene]bis(4,1-phenyleneoxy)]bis[N,N-dimethyl--->Magnesium, iodo(1-methylethyl)- (9CI)-->Azulene, 3-[2,2-bis(4-methoxyphenyl)ethenyl]-1,4-dimethyl-7-(1-methylethyl)--->Azulene-->Methylboronic acid | | Preparation Products | GUM GUAIAC-->Guaiacwood oil-->[1,4-Dimethyl-7-(1-methylethyl)-2-azulenyl]phenylmethanone |
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