3-aminopropanenitrile hydrochloride manufacturers
|
| | 3-aminopropanenitrile hydrochloride Basic information |
| | 3-aminopropanenitrile hydrochloride Chemical Properties |
| | 3-aminopropanenitrile hydrochloride Usage And Synthesis |
| Uses | β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes[1][2]. | | in vivo | β-Aminopropionitrile (BAPN) (100 mg/kg/day; p.o.; 6 weeks) reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats[1].
β-Aminopropionitrile monofumarate (1 g/kg/day; p.o.; 4 weeks) induces thoracic aortic dissection in C57BL/6 mice[3]. | Animal Model: | Male Wistar rats of 150 g, high-fat diet (HFD) model[1] | | Dosage: | 100 mg/kg/day | | Administration: | In the drinking water, 6 weeks | | Result: | Significantly prevented the rise in body weight in HFD rats, but not in animals that were fed a standard diet. Reduced the increase in the weight of white adipose tissue (both epididymal and lumbar) in obese animals and attenuated their enhanced adiposity. Improved fasted glucose and insulin levels and consequently reduced HOMA index in the HFD group. Improved insulin signalling in adipose tissue from obese animals. |
| Animal Model: | C57BL/6 mice[3] | | Dosage: | 1 g/kg/day | | Administration: | In the drinking water, 4 weeks | | Result: | Induce thoracic aortic dissection (TAD) in all mice with 24h of Ang II infusion. Caused 87% of C57BL/6 mice to develop TAD without Ang II. |
| | IC 50 | Lysyl Oxidase | | References | [1] Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51. DOI:10.1242/dmm.020107
[2] Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8. DOI:10.3892/or.2012.2146
[3] Ren W, et al. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep. 2016 Jun 22;6:28149. DOI:10.1038/srep28149 |
| | 3-aminopropanenitrile hydrochloride Preparation Products And Raw materials |
|