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| | 13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester Basic information |
| Product Name: | 13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester | | Synonyms: | 13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester;13-Azido-5,8,11-trioxa-2-azatridecanoic acid 9H-fluoro-9-yl methyl ester;FmocNH-PEG3-CH2CH2N3;FmocNH-PEG3-CH2CH2N3/5,8,11-Trioxa-2-azatridecanoic acid, 13-azido-, 9H-fluoren-9-ylmethyl ester;(9H-Fluoren-9-yl)methyl (2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)carbamate | | CAS: | 1172605-58-1 | | MF: | C23H28N4O5 | | MW: | 440.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1172605-58-1.mol |  |
| | 13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester Chemical Properties |
| | 13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester Usage And Synthesis |
| Uses | Fmoc-N-amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Fmoc-N-amido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | Biological Activity | Fmoc-N-amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | 13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester Preparation Products And Raw materials |
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