Acetazolamide sodium manufacturers
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| | Acetazolamide sodium Basic information |
| Product Name: | Acetazolamide sodium | | Synonyms: | acetazolamidesodiumsalt;diamoxsodium;n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt;n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt;SODIUMACETAZOLAMIDE;Acetazolamide sodium | | CAS: | 1424-27-7 | | MF: | C4H7N4NaO3S2 | | MW: | 246.23 | | EINECS: | | | Product Categories: | | | Mol File: | 1424-27-7.mol |  |
| | Acetazolamide sodium Chemical Properties |
| storage temp. | 4°C, away from moisture | | solubility | DMSO : 100 mg/mL (407.76 mM; Need ultrasonic) | | form | Solid | | color | Powder fine white |
| Toxicity | ACETAZOLAMIDE SODIUM SALT SODIUMACETAZOLAMIDE |
| | Acetazolamide sodium Usage And Synthesis |
| Uses | Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6]. | | Definition | ChEBI: Acetazolamide sodium is an organic sodium salt. It contains an acetazolamide and an acetazolamide(1-). | | Brand name | Diamox (Duramed). | | Safety Profile | ACETAZOLAMIDE SODIUM SALT SODIUMACETAZOLAMIDE | | in vivo | Acetazolamide (40 mg/kg) significantly potentiates the inhibitory effect of MS-275 on tumorigenesis in neuroblastoma (NB) SH-SY5Y xenografts[3].
Acetazolamide (40 mg/kg) and/or MS-275 treatment reduce expression of HIF1-α and CAIX in NB SH-SY5Y xenograft[3].
Acetazolamide (40 mg/kg), MS-275 and Acetazolamide+MS-275 reduce expression of mitotic and proliferative markers in NB SH-SY5Y xenografts[3].
Acetazolamide (50 mg/kg; PO, for 3 days) significantly reduces the gonococcal load in the vagina of infected mice by 90%[6]. | | IC 50 | CA Ⅸ | | References | [1] Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156. DOI:10.1186/s12885-017-3126-7
[2] Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. DOI:10.1016/j.ejmech.2017.03.023
[3] Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306. DOI:10.3892/ol.2018.8529
[4] Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. DOI:10.1097/CRD.0b013e31822b4939
[5] Jabeen E, et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. DOI:10.1016/j.jphotobiol.2013.06.002
[6] Abutaleb NS, et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. DOI:10.1016/j.micpath.2022.105454 |
| | Acetazolamide sodium Preparation Products And Raw materials |
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