B014 manufacturers
- MPT0B014
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- $48.00
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2026-04-22
- CAS:1215208-59-5
- Purity: 99.56%
- Supply Ability: 10g
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| Product Name: | B014 | | Synonyms: | 6-Quinolinyl(3,4,5-trimethoxyphenyl)methanone;B014;MPT0B014;MPT0B014 >=98% (HPLC);Methanone, 6-quinolinyl(3,4,5-trimethoxyphenyl)-;PARP-2-IN-3;MPT0B014, 10 mM in DMSO;Quinolin-6-yl(3,4,5-trimethoxyphenyl)methanone | | CAS: | 1215208-59-5 | | MF: | C19H17NO4 | | MW: | 323.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1215208-59-5.mol |  |
| Boiling point | 513.5±50.0 °C(Predicted) | | density | 1.211±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | pka | 3.84±0.10(Predicted) | | color | white to beige |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| Uses | MPT0B014 is a tubulin polymerization inhibitor. MPT0B014 induces cancer cell apoptosis. MPT0B014 can be used for the research of cancer[1]. | | in vivo | The combination of MPT0B014 (100 mg/kg; i.v./i.p.; daily for 25 days) and 25 mg/kg Erlotinib (HY-50896) significantly improves A549 tumor inhibition in mice[1]. | Animal Model: | Nude athymic mice, A549 xenografts[1] | | Dosage: | 100 mg/kg alone or in combination with 25 mg/kg Erlotinib (HY-50896) | | Administration: | i.v./i.p., daily for 25 days | | Result: | The combined treatment resulted in more significant tumor growth delay (28%) compared with treatment alone (7%). The combination produced significantly higher anti-tumor activity. The growth of A549 cancer cell xenografts was suppressed by 11, 21 and 49% (tumor growth inhibition) after treatment with MPT0B014, Erlotinib and MPT0B014 plus Erlotinib, respectively.
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| | References | [1] Tsai AC, et al. In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells. Br J Pharmacol. 2014 Jan;171(1):122-33. DOI:10.1111/bph.12427 |
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