LY2365109盐酸盐
| 中文名称 | LY2365109盐酸盐 |
|---|---|
| 中文同义词 | LY2365109盐酸盐;2-((2-(4-(苯并[D][1,3]二氧杂戊环-5-基)-2-(叔丁基)苯氧基)乙基)(甲基)氨基)乙酸盐酸盐;LY2365109盐酸盐,10 MM DMSO 溶液;LY-2365109 hydrochloride (LY2365109 hydrochloride) |
| 英文名称 | LY2365109 (hydrochloride) |
| 英文同义词 | LY2365109 HCl;neuroblastoma,Glycine transporters,LY2365109,Human,GlyT,LY-2365109 hydrochloride,LY 2365109,glycine,seizure,LY2365109 hydrochloride,LY-2365109,uptake,Inhibitor,inhibit;2-((2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)(methyl)amino)acetic acid hydrochloride;LY2365109 hydrochloride, 10 mM in DMSO;LY-2365109 hydrochloride (LY2365109 hydrochloride) |
| CAS号 | 1779796-27-8 |
| 分子式 | C22H28ClNO5 |
| 分子量 | 421.92 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1779796-27-8.mol |
| 结构式 |  |
LY2365109盐酸盐 性质
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 在 DMSO 中溶解度为 100 mM，在乙醇中溶解度为 50 mM |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
LY2365109 hydrochloride 是一种高效、选择性的 GlyT1 抑制剂，抑制过表达 hGlyT1 细胞摄取谷氨酸的 IC50 值为 15.8 nM.
|
hGlyT1 15.8 nM nM (IC 50 ) |
LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.
LY2365109 hydrochloride increases seizure thresholds in mice.
| Animal Model: | Male Sprague-Dawley rats (250-300 g) |
| Dosage: | 0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Oral administration |
| Result: | Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing. |