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| | Azadibenzocyclooctyne-PEG4-acid Basic information |
| Product Name: | Azadibenzocyclooctyne-PEG4-acid | | Synonyms: | Azadibenzocyclooctyne-PEG4-acid;DBCO-NH-PEG4-CH2CH2COOH;DBCO-PEG4-CH2CH2COOH;DBCO-NHCO-PEG5-acid;DBCO-PEG5-acid,DBCO-PEG5-COOH;4,7,10,13,16-Pentaoxa-20-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-19,23-dioxo-;ADIBO-PEG(5)-acid;Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid | | CAS: | 1870899-46-9 | | MF: | C32H40N2O9 | | MW: | 596.67 | | EINECS: | | | Product Categories: | DBCO | | Mol File: | 1870899-46-9.mol |  |
| | Azadibenzocyclooctyne-PEG4-acid Chemical Properties |
| Boiling point | 855.9±65.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DMF, DCM | | pka | 4.28±0.10(Predicted) |
| | Azadibenzocyclooctyne-PEG4-acid Usage And Synthesis |
| Description | DBCO-NHCO-PEG5-acid is an analog of DBCO-Acid with a hydrophilic PEG spacer arm, which improves water solubility. This reagent is a non-activated building block with enhanced solubility in aqueous media and can thus be used to derivatize amine-containing molecule through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions. | | Uses | DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-NHCO-PEG4-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | Cleavable Linker; PEGs | | References | [1] Vukic Soskic, et al. Method for binding biologically active molecules to surfaces. DE102014215208A1. |
| | Azadibenzocyclooctyne-PEG4-acid Preparation Products And Raw materials |
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