Azadibenzocyclooctyne-PEG4-acid
| 中文名称 | Azadibenzocyclooctyne-PEG4-acid |
|---|---|
| 中文同义词 | 二苯并环辛炔-五聚乙二醇-羧基,DBCO-PEG5-ACID,DBCO-PEG5-COOH;二苯基环辛炔-五聚乙二醇-羧酸;氮杂二苯并环辛炔四聚乙二醇羧乙基;二苯并环辛炔-五聚乙二醇-羧酸;二苯并环辛炔-NHCO-五聚乙二醇-羧酸;AZADIBENZOCYCLOOCTYNE-PEG5-ACID;化合物 DBCO-NHCO-PEG4-acid;二苯并环辛炔-酰胺-五聚乙二醇-羧酸 |
| 英文名称 | Azadibenzocyclooctyne-PEG4-acid |
| 英文同义词 | Azadibenzocyclooctyne-PEG4-acid;DBCO-NH-PEG4-CH2CH2COOH;DBCO-PEG4-CH2CH2COOH;DBCO-NHCO-PEG5-acid;DBCO-PEG5-acid,DBCO-PEG5-COOH;4,7,10,13,16-Pentaoxa-20-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-19,23-dioxo-;ADIBO-PEG(5)-acid;Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid |
| CAS号 | 1870899-46-9 |
| 分子式 | C32H40N2O9 |
| 分子量 | 596.67 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1870899-46-9.mol |
| 结构式 |  |
Azadibenzocyclooctyne-PEG4-acid 性质
| 沸点 | 855.9±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 溶解度 | 溶于水、DMSO、DMF、DCM |
| 酸度系数(pKa) | 4.28±0.10(Predicted) |
DBCO-Amide-PEG5-acid 是一种 PROTAC 连接桥，属于 PEG 类。DBCO-Amide-PEG5-acid 可用于合成一系列 PROTAC 分子。DBCO-Amide-PEG5-acid 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
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Cleavable
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PEGs
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.