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| | N-Me-N-(PEG4-acid)2 Basic information |
| Product Name: | N-Me-N-(PEG4-acid)2 | | Synonyms: | N-Me-N-(PEG4-acid)2;N-Me-N-bis(PEG4-acid) HCl salt;4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-methyl-;MeN-(PEG4-CH2CH2COOH)2 | | CAS: | 2055014-77-0 | | MF: | C23H45NO12 | | MW: | 527.6 | | EINECS: | | | Product Categories: | | | Mol File: | 2055014-77-0.mol |  |
| | N-Me-N-(PEG4-acid)2 Chemical Properties |
| Boiling point | 637.4±55.0 °C(Predicted) | | density | 1.158±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | form | Viscous Liquid | | pka | 3.97±0.10(Predicted) | | color | Colorless to off-white |
| | N-Me-N-(PEG4-acid)2 Usage And Synthesis |
| Description | N-Me-N-bis(PEG4-acid) HCl salt is a crosslinker linker containing two PEG4-acid groups. The two terminal carboxylic acid groups can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound. The water solubility properties of the PEG linker are enhanced with longer PEG chains. | | Uses | N-Me-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-Me-N-(PEG4-acid)2 Preparation Products And Raw materials |
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