ALKYNE-PEG9-BR
| 中文名称 | ALKYNE-PEG9-BR |
|---|---|
| 中文同义词 | 丙炔-九聚乙二醇-溴;炔-九聚乙二醇-溴;丙炔基-PEG9-溴;炔丙基PEG9-溴化物;炔丙基-九聚乙二醇-溴;1-溴-3,6,9,12,15,18,21,24,27-九氧杂三十烷-29-炔;化合物 Propargyl-PEG9-bromide;炔丙基-九甘醇-溴 |
| 英文名称 | Propargyl-PEG9-bromide |
| 英文同义词 | Propargyl-PEG9-bromide;Alkyne-PEG9-Br;Propargyl-PEG9-Br;3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yne, 1-bromo-;Propargyl-PEG9-Br/3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yne, 1-bromo-;1-Bromo-3,6,9,12,15,18,21,24,27-nonaoxatriacont-29-yne;Alkeyn-PEG9-Br |
| CAS号 | 2055042-83-4 |
| 分子式 | C21H39BrO9 |
| 分子量 | 515.43 |
| EINECS号 | |
| 相关类别 | 助剂 |
| Mol文件 | 2055042-83-4.mol |
| 结构式 |  |
ALKYNE-PEG9-BR 性质
| 沸点 | 525.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.200±0.06 g/cm3(Predicted) |
Propargyl-PEG9-bromide 是一种 PROTAC 连接桥，属于 PEG 类。Propargyl-PEG9-bromide 可用于合成一系列 PROTAC 分子。Propargyl-PEG9-bromide 是一种不可降解 (non-cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
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Non-cleavable
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PEGs
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.