k-80003

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k-80003 manufacturers

  • K-80003
  • K-80003 pictures
  • $64.00
  • 2026-07-27
  • CAS:1292821-90-9
  • Purity: 99.76%
  • Supply Ability: 10g
  • K-80003
  • K-80003 pictures
  • $64.00
  • 2026-07-27
  • CAS:1292821-90-9
  • Purity: 99.76%
  • Supply Ability: 10g
k-80003 Basic information
Product Name:k-80003
Synonyms:k-80003;K-80003 (TX-803);TX-803;1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(1-methylethyl)phenyl]methylene]-, (1Z)-;K 80003,K80003;K-80003, 10 mM in DMSO
CAS:1292821-90-9
MF:C22H21FO2
MW:336.4
EINECS:
Product Categories:
Mol File:1292821-90-9.mol
k-80003 Structure
k-80003 Chemical Properties
Boiling point 491.6±40.0 °C(Predicted)
density 1.192±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 30 mg/mL (89.18 mM)
pka4.27±0.10(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
k-80003 Usage And Synthesis
UsesK-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.
DefinitionChEBI: [5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid is a sulindac-based non-steroidal anti-inflammatory drug. It has a role as a non-steroidal anti-inflammatory drug. It is functionally related to an acetic acid.
in vivo

K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity[1].

References[1] Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73. DOI:10.1016/j.ccr.2010.04.023
[2] Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα. Nat Commun. 2017 Jul 17;8:16066. DOI:10.1038/ncomms16066
k-80003 Preparation Products And Raw materials
Tag:k-80003(1292821-90-9) Related Product Information
1H-Indene-3-acetic acid, 5-fluoro- K-80001 1H-Indene-3-acetic acid, 2-methyl- Sulindac sulfide (5-Fluoro-2-methyl-1H-inden-3-yl)acetic acid k-80003