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Uridine, 5'-azido-5'-deoxy-2'-O-methyl- manufacturers
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| | Uridine, 5'-azido-5'-deoxy-2'-O-methyl- Basic information |
| Product Name: | Uridine, 5'-azido-5'-deoxy-2'-O-methyl- | | Synonyms: | Uridine, 5'-azido-5'-deoxy-2'-O-methyl-;5'-Azido-5'-deoxy-2'-O-methyluridine;5’-Azido-5’-deoxy-2’-O-methyluridine;1-[(2R,3R,4R,5R)-5-(azidomethyl)-4-hydroxy-3-methoxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione | | CAS: | 194034-68-9 | | MF: | C10H13N5O5 | | MW: | 283.24 | | EINECS: | | | Product Categories: | | | Mol File: | 194034-68-9.mol |  |
| | Uridine, 5'-azido-5'-deoxy-2'-O-methyl- Chemical Properties |
| | Uridine, 5'-azido-5'-deoxy-2'-O-methyl- Usage And Synthesis |
| Uses | 5’-Azido-5’-deoxy-2’-O-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-2’-O-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
| | Uridine, 5'-azido-5'-deoxy-2'-O-methyl- Preparation Products And Raw materials |
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