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M-3M3FBS manufacturers
- m-3M3FBS
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- $43.00
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2026-06-02
- CAS:200933-14-8
- Purity: 99.92%
- Supply Ability: 10g
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| | M-3M3FBS Basic information |
| Product Name: | M-3M3FBS | | Synonyms: | N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH;Phospholipase C Activator,;M-3M3FBS;2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE;Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem;Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]- | | CAS: | 200933-14-8 | | MF: | C16H16F3NO2S | | MW: | 343.36 | | EINECS: | | | Product Categories: | Lipid signaling | | Mol File: | 200933-14-8.mol |  |
| | M-3M3FBS Chemical Properties |
| Melting point | 114-114.8 °C(lit.) | | Boiling point | 420.0±55.0 °C(Predicted) | | density | 1.316±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: 92 mg/mL | | form | solid | | pka | 7.82±0.10(Predicted) | | color | white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | | InChI | 1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3 | | InChIKey | ZIIUUSVHCHPIQD-UHFFFAOYSA-N | | SMILES | Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc2cccc(c2)C(F)(F)F |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | M-3M3FBS Usage And Synthesis |
| Description | m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3 | | Uses | m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation. | | Uses | m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2. | | Definition | ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide. | | Biological Activity | Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types. | | Biochem/physiol Actions | First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms). | | storage | Store at RT | | References | [1] YOE-SIK BAE. Identification of a compound that directly stimulates phospholipase C activity.[J]. Molecular Pharmacology, 2003, 63 5: 1043-1050. DOI:10.1124/mol.63.5.1043
[2] YOUL-NAM LEE . The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis[J]. Cancer letters, 2005, 222 2: Pages 227-235. DOI:10.1016/j.canlet.2004.09.017
[3] JELENA KRJUKOVA. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation[J]. British Journal of Pharmacology, 2009, 143 1: 3-7. DOI:10.1038/sj.bjp.0705911 |
| | M-3M3FBS Preparation Products And Raw materials |
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