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| | Val-Cit-pAb-mmad Basic information |
| Product Name: | Val-Cit-pAb-mmad | | Synonyms: | Vat-Cit-PAB-MMAD;Vat-Cit-PAB-Monomethyl Dolastatin 10;Vat-Cit-PABMonomethyl;L-Valinamide, N-methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-;4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-3-methoxy-1-((R)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate;Val-Cit-pAb-mmad | | CAS: | 1415329-13-3 | | MF: | C60H93N11O11S | | MW: | 1176.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1415329-13-3.mol |  |
| | Val-Cit-pAb-mmad Chemical Properties |
| Boiling point | 1237.168±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.193±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 13.744±0.46(predicted) |
| | Val-Cit-pAb-mmad Usage And Synthesis |
| Uses | Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB. | | IC 50 | Auristatin | | References | [1] Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9. DOI:10.1038/nchem.2415 |
| | Val-Cit-pAb-mmad Preparation Products And Raw materials |
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