(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol

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(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Suppliers list
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:Nedisertib
CAS:1637542-33-6
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: BOC Sciences
Tel: 16314854226; +8616314854226
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Products Intro: Product Name:Nedisertib
CAS:1637542-33-6
Package:100 mg Remarks:Please reach out to us for more information about custom solutions.
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:M3814 MSC2490484A
CAS:1637542-33-6
Purity:99% Package:5KG;1KG Remarks:M3814 MSC2490484A
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Nedisertib (M3814, MSC2490484A)
CAS:1637542-33-6
Purity:98% Package:5mg Remarks:V26351
Company Name: Chemtour Biotech Co., Ltd
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Products Intro: Product Name:M3814
CAS:1637542-33-6
Purity:99% Package:5KG;1KG
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Basic information
Product Name:(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol
Synonyms:(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol;M-3814;MSC2490484A;M3814 (MSC2490484A);MSC2490484A; MSC-2490484A; MSC 2490484A; M3814; M-3814; M 3814; NEDISERTIB;M-3814(nedisertib);3-Pyridazinemethanol, α-[2-chloro-4-fluoro-5-[7-(4-morpholinyl)-4-quinazolinyl]phenyl]-6-methoxy-, (αS)-;Nedisertib (M3814, MSC2490484A)
CAS:1637542-33-6
MF:C24H21ClFN5O3
MW:481.91
EINECS:
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Mol File:1637542-33-6.mol
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Structure
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Chemical Properties
Melting point >198°C (dec.)
Boiling point 716.0±60.0 °C(Predicted)
density 1.405±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
pka11.35±0.20(Predicted)
form Solid
color Pale Yellow to Light Green
InChIKeyMOWXJLUYGFNTAL-FKEMPHOKNA-N
SMILES[C@H](C1=CC(C2=C3C(=NC=N2)C=C(N2CCOCC2)C=C3)=C(F)C=C1Cl)(C1=NN=C(OC)C=C1)O |&1:0,r|
Safety Information
MSDS Information
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Usage And Synthesis
UsesM-3814 is a reagent used in the preparation of serine/threonine protein kinase inhibitors useful for the treatment of cancer.
in vivo

In combination with IR, Nedisertib shows efficacy in all of the 6 mouse models of human cancer. In all models, a dose of 2 Gy administered daily for 1 week in combination with Nedisertib induces statically significant tumor growth inhibition compare to IR alone. Nedisertib, alone or in combination with IR, does not induce significant weight loss or visual signs of toxicity in the mice in any study[1].

IC 50DNA-PK: <3 nM (IC50)
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol Preparation Products And Raw materials
Tag:(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol(1637542-33-6) Related Product Information
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