| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
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sales8178@energy-chemical.com |
- RARECHEM AL BF 0506
-
- $1.00
-
2019-08-02
- CAS:174403-69-1
- Min. Order: 1KG
- Purity: 95-99%
- Supply Ability: 500kg/month
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| | Methyl 4-fluoro-2-methylbenzoate Basic information |
| Product Name: | Methyl 4-fluoro-2-methylbenzoate | | Synonyms: | RARECHEM AL BF 0506;BENZOIC ACID,4-FLUORO-2-METHYL-,METHYL ESTER;4-Fluoro-2-methylbenzoic acid methyl ester;4-Floro-2-methylbenzoic acid methyl ester;2-Methyl-4-fluorobenzoic acid methyl ester;methyl 2-methyl-4-fluorobenzoate;Baloxavir Marboxil Impurity 58;methyl 4-fluoro-2-methylbenzoate | | CAS: | 174403-69-1 | | MF: | C9H9FO2 | | MW: | 168.16 | | EINECS: | | | Product Categories: | | | Mol File: | 174403-69-1.mol |  |
| | Methyl 4-fluoro-2-methylbenzoate Chemical Properties |
| Boiling point | 206℃ | | density | 1.137 | | Fp | 77℃ | | storage temp. | Sealed in dry,Room Temperature | | form | Liquid | | color | Colorless |
| | Methyl 4-fluoro-2-methylbenzoate Usage And Synthesis |
| Chemical Properties | off-white powder | | Uses | Methyl 4-fluoro-2-methylbenzoate is an impurity of baloxavir and can be used for new drug application and research.
| | Synthesis | Step 1. Synthesis of methyl 4-fluoro-2-methylbenzoate: 4-fluoro-2-methylbenzoic acid (50 g, 324.38 mmol) was mixed with thionyl chloride (SOCl2, 77 g, 648.76 mmol) in methanol (200 mL), and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to afford methyl 4-fluoro-2-methylbenzoate as a brown oil (52 g, 95% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 7.92-7.98 (m, 1H), 6.88-6.95 (m, 2H), 3.90 (s, 3H), 2.61 (s, 3H). | | References | [1] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 60
[2] Patent: WO2010/69966, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: US6342504, 2002, B1. Location in patent: Page column 119
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 24, p. 6707 - 6713
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1628 - 1631 |
| | Methyl 4-fluoro-2-methylbenzoate Preparation Products And Raw materials |
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