LOLJEILMPWPILA-WZDCOHRSSA-N manufacturers
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| | LOLJEILMPWPILA-WZDCOHRSSA-N Basic information |
| Product Name: | LOLJEILMPWPILA-WZDCOHRSSA-N | | Synonyms: | LOLJEILMPWPILA-WZDCOHRSSA-N;8-iso-15-keto Prostaglandin F2.beta.;9β,11α-dihydroxy-15-oxo-(8β)-prosta-5Z,13E-dien-1-oic acid;Prosta-5,13-dien-1-oic acid, 9,11-dihydroxy-15-oxo-, (5Z,8β,9β,11α,13E)-;8-iso-15-keto Prostaglandin F2β | | CAS: | 1621482-36-7 | | MF: | C20H32O5 | | MW: | 352.47 | | EINECS: | | | Product Categories: | | | Mol File: | 1621482-36-7.mol |  |
| | LOLJEILMPWPILA-WZDCOHRSSA-N Chemical Properties |
| Boiling point | 535.2±50.0 °C(Predicted) | | density | 1.149±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | | pka | 4.76±0.10(Predicted) |
| | LOLJEILMPWPILA-WZDCOHRSSA-N Usage And Synthesis |
| Description | 8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α. 8-iso-15-keto PGF2β is a potential metabolite of 8-iso PGF2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2β. | | Uses | 8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs[1][2]. | | Definition | ChEBI: 8-iso-15-keto Prostaglandin F2beta is a prostanoid. | | References | [1] Janssen LJ, et al. Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles. Br J Pharmacol. 2001 Jan;132(1):127-34. DOI:10.1038/sj.bjp.0703784
[2] Janssen LJ, et al. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J Pharmacol Exp Ther. 2002 Jun;301(3):1060-6. DOI:10.1124/jpet.301.3.1060 |
| | LOLJEILMPWPILA-WZDCOHRSSA-N Preparation Products And Raw materials |
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