4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline manufacturers
- KRAS inhibitor-9
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- $55.00
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2026-07-27
- CAS:300809-71-6
- Purity: 99.94%
- Supply Ability: 10g
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| | 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline Basic information |
| Product Name: | 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline | | Synonyms: | 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline;0375-0604;Benzenamine, 4-(2-benzothiazolylthio)-3-chloro-;DUN09716;non-small,proliferation,inhibit,KRAS inhibitor 9,KRAS inhibitor9,cytotoxicity,Apoptosis,cell,H460,mutant,H2122,H358,lung,Inhibitor,Ras,cancer,cells,KRAS inhibitor-9,GTP-KRAS;0375-0604 (KRAS inhibitor-9);KRAS inhibitor-9, 10 mM in DMSO;KRAS inhibitor-9/300809-71-6 | | CAS: | 300809-71-6 | | MF: | C13H9ClN2S2 | | MW: | 292.81 | | EINECS: | | | Product Categories: | | | Mol File: | 300809-71-6.mol | ![4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline Structure](CAS/20180601/GIF/300809-71-6.gif) |
| | 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline Chemical Properties |
| Boiling point | 492.4±55.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (853.80 mM) | | pka | 2.37±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline Usage And Synthesis |
| Uses | KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1]. | | References | [1] Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14. DOI:10.3389/fphar.2017.00823 |
| | 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline Preparation Products And Raw materials |
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