2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide

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Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide Basic information
Product Name:2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide
Synonyms:2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide;Benzenesulfonamide, 5-[4-[[4-(aminosulfonyl)phenyl]amino]-1-phthalazinyl]-2-methyl-;ENPP3 Inhibitor;5-[4-[[4-(aminosulfonyl)phenyl]amino]-1-phthalazinyl]-2-methyl-benzenesulfonamide
CAS:333413-02-8
MF:C21H19N5O4S2
MW:469.54
EINECS:
Product Categories:
Mol File:333413-02-8.mol
2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide Structure
2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide Chemical Properties
storage temp. -20°C
solubility DMF: insol,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
form A crystalline solid
Safety Information
MSDS Information
2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide Usage And Synthesis
UsesCA IX-IN-3 (Compound 27) is a selective and potent carbonic anhydrase IX (CA IX) inhibitor with an IC50 of 0.48 nM[1].
Biological ActivityENPP3 inhibitor is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3; Ki = 53.7 nM).1 It is selective for ENPP3 over ENPP1, ENPP2, tissue-nonspecific alkaline phosphatase (TNAP), ecto-5′-nucleotidase (CD73), nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), NTPDase 2, and NTPDase 3. ENPP3 inhibitor also inhibits carbonic anhydrase II (CAII) and CAIX (Kis = 74.7 and 20.3 nM, respectively).
IC 50CA Ⅸ: 0.48 nM (IC50)
References1.Lee, S.-Y., Namasivayam, V., Boshta, N.M., et al.Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapyRSC Med. Chem.12(7)1187-1206(2021)
2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide Preparation Products And Raw materials
Tag:2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide(333413-02-8) Related Product Information
ENPP3 Inhibitor 1 ENPP3 Inhibitor 5J Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)- Benzenesulfonic acid, 4-(trifluoromethoxy)-, 4-[(4-methylbenzoyl)amino]phenyl ester h-e5'NT Inhibitor 5C Benzolamide