|
|
| | (-)-HYDROXYCITRIC ACID CALCIUM SALT Basic information |
| Product Name: | (-)-HYDROXYCITRIC ACID CALCIUM SALT | | Synonyms: | (-)-HYDROXYCITRIC ACID CALCIUM SALT;HYDROXYCITRIC ACID CALCIUM SALT, (-)-;5-Hydroxyindo;SUPERCITRIMAX;HYDROXYCITRICACID(-ISOMER);HYDROXYCITRIC ACID, (-)-(P);D-erythro-Pentaric acid, 3-C-carboxy-2-deoxy-;(-)-Hydroxycitric Acid | | CAS: | 27750-10-3 | | MF: | C6H8O8 | | MW: | 208.12 | | EINECS: | | | Product Categories: | | | Mol File: | 27750-10-3.mol |  |
| | (-)-HYDROXYCITRIC ACID CALCIUM SALT Chemical Properties |
| Boiling point | 393.3±42.0 °C(Predicted) | | density | 1.947±0.06 g/cm3(Predicted) | | pka | 2.90±0.28(Predicted) | | form | Solid | | color | White to off-white |
| | (-)-HYDROXYCITRIC ACID CALCIUM SALT Usage And Synthesis |
| Uses | (-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss[1][2]. | | Definition | ChEBI: Garcinia acid is a carbonyl compound. | | in vivo | (-)-Hydroxycitric acid (1.0 mg/kg embryos, injection) reduces lipid droplets accumulation, triglyceride content, lipogenesis factors mRNA level and increases lipolysis factors mRNA expression in chicken embryos[3].
(-)-Hydroxycitric acid (p.o., once) shows a LD50 of greater than 5000 mg/kg in fasted male and female Albino rats[5].
(-)-Hydroxycitric acid (1000-3000 mg/kg diet for 8 weeks) reduces body weight gain, increases feed conversion ratio, and promotes protein synthesis in rats[6].
| | References | [1] B. S. Jena, et al. Chemistry and Biochemistry of ()-Hydroxycitric Acid from Garcinia. J. Agric. Food Chem. 2002, 50, 1, 10-22.
[2] Hayamizu K, et al. Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Curr Ther Res Clin Exp. 2003 Sep;64(8):551-67. DOI:10.1016/j.curtheres.2003.08.006
[3] Li S, et al. (-)-Hydroxycitric Acid Influenced Fat Metabolism via Modulating of Glucose-6-phosphate Isomerase Expression in Chicken Embryos. J Agric Food Chem. 2019 Jul 3;67(26):7336-7347. DOI:10.1021/acs.jafc.9b02330
[4] Li L, et al. (-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes. Cell Physiol Biochem. 2017;43(2):812-831. DOI:10.1159/000481564
[5] Ohia SE, et al. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002 Sep;238(1-2):89-103. DOI:10.1023/a:1019911205672
[6] Han N, et al. (-)-Hydroxycitric Acid Nourishes Protein Synthesis via Altering Metabolic Directions of Amino Acids in Male Rats. Phytother Res. 2016 Aug;30(8):1316-29. DOI:10.1002/ptr.5630 |
| | (-)-HYDROXYCITRIC ACID CALCIUM SALT Preparation Products And Raw materials |
|