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| | CASPASE-1 INHIBITOR TFA SALT Basic information |
| Product Name: | CASPASE-1 INHIBITOR TFA SALT | | Synonyms: | CASPASE-1 INHIBITOR TFA SALT;Z-WEHD-FMK-TFA;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA;N-[(Phenylmethoxy)carbonyl]-L-tryptophyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-histidinamide methyl ester;Caspase-1/ICE Inhibitor Z-WEHD-FMK;Z-WE(OME)HD(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE;L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester (9CI) | | CAS: | 210345-00-9 | | MF: | C37H42FN7O10 | | MW: | 763.77 | | EINECS: | | | Product Categories: | Apoptosis | | Mol File: | 210345-00-9.mol |  |
| | CASPASE-1 INHIBITOR TFA SALT Chemical Properties |
| Boiling point | 1129.2±65.0 °C(Predicted) | | density | 1.349±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; ≥26.32 mg/mL in EtOH with ultrasonic; ≥46.33 mg/mL in DMSO | | form | Powder | | pka | 11.06±0.46(Predicted) | | color | Light yellow to yellow |
| | CASPASE-1 INHIBITOR TFA SALT Usage And Synthesis |
| Uses | Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4]. | | Biological Activity | treatment of infected cells with pan-caspase inhibitor iv and z-wehd-fmk, an inhibitor of inflammatory caspases, elicited a near-complete blockage of c. trachomatis-induced cleavage of golgin-84. golgin-84 cleavage was blocked via treatment of infected cells with z-wehd-fmk, resulting in a lack of golgi fragmentation and a 2-log reduction in numbers of infectious bacteria.we treated infected cells with z-wehd-fmk, effectively preventing golgi fragmentation, or with dmso as a control and then labelled cells with fluorescent ceramide. confocal images revealed that ceramide was rapidly incorporated into the inclusion membrane within dmso-treated cells and accumulated inside the inclusion in bacterial membranes. in contrast, z-wehd-fmk-treated cells were only slightly fluorescent as the majority of lipid accumulated in a golgi-like structure outside the inclusion1.general caspase inhibitor (z-asp-chz-dcb) and capase-5 inhibitor (z-wehd-fmk) could not induce rrna fragmentation treated with ecyd. caspase-5 (icerei ill/ty), member of ice protease, activated pathway may be concerned with ecyd induced rrna fragmentation2. | | target | caspase-5 | | IC 50 | Cathepsin B; Caspase-1 | | references | 1. d. heuer, a.r. lipinski et al. chlamydia causes fragmentation of the golgi compartment to ensure reproduction. nature, 457, 2009 2. kamada, s., funahashi, y. and tsujimoto, y.(1997) cell death diff. 4, 473-478. |
| | CASPASE-1 INHIBITOR TFA SALT Preparation Products And Raw materials |
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