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| | (5-Amino-1H-1,2,4-triazol-3-yl)methanol Basic information |
| Product Name: | (5-Amino-1H-1,2,4-triazol-3-yl)methanol | | Synonyms: | ASINEX-REAG BAS 03825303;(3-AMino-1H-1,2,4-triazol-5-yl)Methanol coMpound with 2-hydroxyacetic acid;(5-amino-2H-1,2,4-triazol-3-yl)methanol;Acetic acid, hydroxy-, compd. with 5-amino-1H-1,2,4-triazole-3-methanol (1:1);NSC513582;ZERO/004602;ZINC02415220;(3-Amino-1H-1,2,4-triazol-5-yl) | | CAS: | 63870-39-3 | | MF: | C3H6N4O | | MW: | 114.11 | | EINECS: | | | Product Categories: | | | Mol File: | 63870-39-3.mol |  |
| | (5-Amino-1H-1,2,4-triazol-3-yl)methanol Chemical Properties |
| Hazard Codes | Xi | | TSCA | TSCA listed |
| | (5-Amino-1H-1,2,4-triazol-3-yl)methanol Usage And Synthesis |
| Synthesis | Aminoguanidine bicarbonate (23.5 g, 172 mmol) was added in batches to a mixture of ethanoic acid (26.2 g, 345 mmol) and water (10 mL) over a period of 0.1 hours. During the addition, the reaction mixture was gently heated to maintain the internal temperature at 25 °C. Subsequently, concentrated nitric acid (1.0 mL) was added slowly and dropwise to the reaction system, and then the reaction mixture was heated to an internal temperature of 104-108 °C over 22 hours. Upon completion of the reaction, the heating was stopped and the solution was allowed to cool naturally with stirring. The slurry cooled to 10 °C was continued to be stirred for 2 h. Subsequently, it was filtered and the filter cake was washed with ethanol (EtOH). The resulting solid was dried overnight under vacuum to afford the target product (5-amino-1H-1,2,4-triazol-3-yl) methanol ethanolate (Product 88a, 29.5 g, 85% yield). Mass spectrometry analysis: calculated value (M + H)+ = 115, measured value (M + H)+ = 115. | | References | [1] Patent: WO2012/83105, 2012, A1. Location in patent: Page/Page column 101
[2] Patent: WO2007/23381, 2007, A1. Location in patent: Page/Page column 54-55
[3] Patent: WO2004/74270, 2004, A2. Location in patent: Page 300
[4] Patent: US2005/176701, 2005, A1. Location in patent: Page/Page column 144 |
| | (5-Amino-1H-1,2,4-triazol-3-yl)methanol Preparation Products And Raw materials |
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