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| | (3-BROMO-4-CHLORO-PHENYL)-METHANOL Basic information |
| Product Name: | (3-BROMO-4-CHLORO-PHENYL)-METHANOL | | Synonyms: | (3-BROMO-4-CHLORO-PHENYL)-METHANOL;3-Bromo-4-chlorobenzyl alcohol;3-Bromo-4-chlorobenzenemethanol;(3-Bromo-4-chlorophenyl);3-Bromo-4-chlorobenzyl alcohol 97%;Benzenemethanol, 3-bromo-4-chloro- | | CAS: | 329218-12-4 | | MF: | C7H6BrClO | | MW: | 221.48 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | (3-BROMO-4-CHLORO-PHENYL)-METHANOL Chemical Properties |
| Boiling point | 307.0±27.0 °C(Predicted) | | density | 1.685 | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.89±0.10(Predicted) | | form | solid | | color | Off White |
| | (3-BROMO-4-CHLORO-PHENYL)-METHANOL Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-bromo-4-chlorobenzyl alcohol from 3-bromo-4-chlorobenzoic acid:
A. To a mixture of 3-bromo-4-chlorobenzoic acid (10.0 g, 42.5 mmol) in THF (50 mL) was slowly added 1.0 M borane-THF solution (55.3 mL, 55.3 mmol) under nitrogen protection and at 0 °C. The reaction mixture was stirred overnight at room temperature and then carefully poured into a mixture of NaHCO3/H2O/ice and extracted with EtOAc. The organic layer was washed with saturated aqueous NaCl, dried over MgSO4, filtered and concentrated under reduced pressure to afford the target product 3-bromo-4-chlorobenzyl alcohol (9.4 g, 100%) as a clear, colorless oil.1H NMR (300 MHz, CDCl3) δ 7.61 (s, 1H), 7.41 (d, J = 5.1 Hz, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.63 (s, 2H), 2.12 (br s, 1H). | | References | [1] Patent: WO2011/79102, 2011, A1. Location in patent: Page/Page column 132
[2] Synlett, 2014, vol. 25, # 1, p. 123 - 127
[3] Patent: WO2013/142396, 2013, A1. Location in patent: Page/Page column 55
[4] Patent: US2006/154915, 2006, A1. Location in patent: Page/Page column 29
[5] Patent: WO2003/99776, 2003, A1. Location in patent: Page 63 |
| | (3-BROMO-4-CHLORO-PHENYL)-METHANOL Preparation Products And Raw materials |
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