| Company Name: |
Twochem Co.Ltd. |
| Tel: |
021-58111628 15800915896 |
| Email: |
sales@twochem.com |
HC-070 manufacturers
- HC-070
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- $81.00
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2026-07-14
- CAS:1628291-95-1
- Purity: 98.48%
- Supply Ability: 10g
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| Product Name: | HC-070 | | Synonyms: | HC-070;HC-070
(HC070);1H-Purine-2,6-dione, 8-(3-chlorophenoxy)-7-[(4-chlorophenyl)methyl]-3,7-dihydro-1-(3-hydroxypropyl)-3-methyl-;HC-070, 10 mM in DMSO;7-(4-Chlorobenzyl)-8-(3-chlorophenoxy)-1-(3-hydroxypropyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione | | CAS: | 1628291-95-1 | | MF: | C22H20Cl2N4O4 | | MW: | 475.32 | | EINECS: | | | Product Categories: | | | Mol File: | 1628291-95-1.mol |  |
| | HC-070 Chemical Properties |
| Boiling point | 695.4±65.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 62.5 mg/mL (131.49 mM) | | pka | 14.85±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | HC-070 Usage And Synthesis |
| Description | HC-070 is a potent inhibitor of TRPC4 and TRPC5, leading to anxiolytic and antidepressant effects in mice. | | Uses | HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively. | | in vivo | HC-070 (1 mg/kg, p.o.) affects mice with increased evoked anxiety (CCK-4), but shows no effects in the absence of CCK-4. HC-070 (0.3, 1 or 3 mg/kg, p.o.) decreases anxiety in a standard EPM (more light/high anxiety). HC-070 (1 mg/kg) reduces the increased capacity for fear memory in mice subjected to chronic social stress on days 1-15. In addition, HC-070 (1, 3, 10 mg/kg, p.o.) causes reduction in marble burying behavior. HC-070 (0.3, 1, 3, 10 mg/kg, p.o.) also reduces time of immobility in a tail suspension test but does not impact locomotor activity in mice[1]. | | References | [1] Just S, et al. Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225. DOI:10.1371/journal.pone.0191225 |
| | HC-070 Preparation Products And Raw materials |
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