N-Desmethyl rosiglitazone

N-Desmethyl rosiglitazone Suppliers list

Company Name:	Chemsky（shanghai）International Co.,Ltd.
Tel:	021-50135380
Email:	shchemsky@sina.com

N-Desmethyl rosiglitazone manufacturers

N-Desmethyl rosiglitazone Basic information

Product Name:	N-Desmethyl rosiglitazone
Synonyms:	SB 237216;N-Desmethyl Rosiglitazone Solution, 100ppm;5-[[4-[2-(2-pyridinylamino]ethoxy]phenyl]methyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[4-[2-(2-pyridinylamino)ethoxy]phenyl]methyl]-;N-Desmethyl RosiglitazoneQ: What is N-Desmethyl Rosiglitazone Q: What is the CAS Number of N-Desmethyl Rosiglitazone Q: What is the storage condition of N-Desmethyl Rosiglitazone Q: What are the applications of N-Desmethyl Rosiglitazone;N-Desmethyl rosiglitazone
CAS:	257892-31-2
MF:	C17H17N3O3S
MW:	343.4
EINECS:
Product Categories:	Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles;Sulfur & Selenium Compounds
Mol File:	257892-31-2.mol

N-Desmethyl rosiglitazone Chemical Properties

Melting point	177-179°C
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	Off-White to Pale Beige

Safety Information

MSDS Information

N-Desmethyl rosiglitazone Usage And Synthesis

Description	N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone (Item Nos. 71740 \| 71742 \| 11884), a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.
Chemical Properties	White Solid
Uses	A metabolite of Rosiglitazone.
Definition	ChEBI: N-desmethylrosiglitazone is an aromatic ether.
References	[1] J M LEHMANN. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).[J]. The Journal of Biological Chemistry, 1995, 270 22: 12953-12956. DOI: 10.1074/jbc.270.22.12953 [2] KWON-BOK KIM . Simultaneous quantification of rosiglitazone and its two major metabolites, N-desmethyl and p-hydroxy rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study[J]. Journal of Chromatography B, 2009, 877 20: Pages 1951-1956. DOI: 10.1016/j.jchromb.2009.05.001

N-Desmethyl rosiglitazone Preparation Products And Raw materials

Tag:N-Desmethyl rosiglitazone(257892-31-2) Related Product Information

5-(4-Fluorobenzyl)-2,4-thiazolidinedione 5-Hydroxy rosiglitazone-d4 5-[[4-[1,1,2,2-tetradeuterio-2-[(5-hydroxypyridin-2-yl)-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Rosiglitazone maleate 5-[4-[N-(2-Pyridylamino)ethoxy]benzylidene]thiazolidine-2,4-dione 5-[[4-[2-[pyridin-2-yl(trideuteriomethyl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione 5-Hydroxy rosiglitazone Desmethyl rosiglitazone-d4 Rosiglitazone-5-sulfoxy N-Desmethyl rosiglitazone 2,4-Thiazolidinedione AKOS 92116 ROSIGLITAZONE D-TARTRATE Rosiglitazone 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione sodium salt