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| | RARECHEM AL BI 1318 Basic information |
| Product Name: | RARECHEM AL BI 1318 | | Synonyms: | ethyl 2-phenylthiazole-4-carboxylate;RARECHEM AL BI 1318;2-PHENYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;4-THIAZOLECARBOXYLIC ACID, 2-PHENYL-, ETHYL ESTER | | CAS: | 59937-01-8 | | MF: | C12H11NO2S | | MW: | 233.29 | | EINECS: | | | Product Categories: | | | Mol File: | 59937-01-8.mol |  |
| | RARECHEM AL BI 1318 Chemical Properties |
| Melting point | 47 °C | | Boiling point | 365℃ | | density | 1.216 | | Fp | 175℃ | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 0.09±0.10(Predicted) |
| | RARECHEM AL BI 1318 Usage And Synthesis |
| Synthesis | GENERAL METHOD: 4-carboxythiazoline or 4-carboxyoxazoline (0.5 mmol) was dissolved in anhydrous DMF (1 mL), molecular sieves (4 , 100% wt) and copper(II) acetate (9.1 mg, 0.05 mmol). The reaction mixture was stirred at 120 °C for 10 to 24 h under an oxygen atmosphere (using an O2 balloon). After completion of the reaction, the reaction mixture was diluted with ethyl acetate, the organic layer was washed sequentially with water and brine, dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The concentrated residue was purified by silica gel fast column chromatography to obtain the target product 4-carboxythiazole or 4-carboxyoxazole. | | References | [1] Tetrahedron, 2011, vol. 67, # 38, p. 7406 - 7411 |
| | RARECHEM AL BI 1318 Preparation Products And Raw materials |
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