| Company Name: |
TCI Europe |
| Tel: |
320-37350700 |
| Email: |
sales@tcieurope.eu |
| Company Name: |
TCI AMERICA |
| Tel: |
800-4238616 |
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sales@tciamerica.com |
Eltoprazine Dihydrochloride manufacturers
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| | Eltoprazine Dihydrochloride Basic information |
| Product Name: | Eltoprazine Dihydrochloride | | Synonyms: | Eltoprazine Dihydrochloride;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine Dihydrochloride;Eltoprazine 2HCl;Eltoprazine dihydrochloride, 10 mM in DMSO | | CAS: | 143485-51-2 | | MF: | C12H17ClN2O2 | | MW: | 256.73 | | EINECS: | | | Product Categories: | | | Mol File: | 143485-51-2.mol |  |
| | Eltoprazine Dihydrochloride Chemical Properties |
| Melting point | 257 °C(dec.) | | form | powder to crystal | | color | White to Light yellow to Light orange |
| | Eltoprazine Dihydrochloride Usage And Synthesis |
| Uses | Eltoprazine (DU 28853) dihydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine dihydrochloride shows antiaggressive and anxiogenic effects[1][2]. | | in vivo | Rats are chronically treated with Mianserin (10 mg/kg i.p.) or Eltoprazine (1 mg/kg i.p.) and are tested in the elevated plus-maze test for anxiety. Mianserin and Eltoprazine display opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while Eltoprazine shows anxiogenic-like ones[2]. | | References | [1] Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177(1-2):55-66. DOI:10.1016/0014-2999(90)90549-l
[2] Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31. DOI:10.1016/0014-2999(94)90035-3 |
| | Eltoprazine Dihydrochloride Preparation Products And Raw materials |
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