那可汀
| 中文名称 | 那可汀 |
|---|---|
| 中文同义词 | 那可汀;(S,R)-诺司卡品;诺司卡品;诺斯卡品;(S,R)-那可汀;纳可丁;那可汀[鹼];那可丁 USP标准品 |
| 英文名称 | Narcotine |
| 英文同义词 | ,2,3,4-tetrahydroisoquinaline;[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone;1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-;1-alpha-Narcotine;5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4;5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4;6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one;nsc5366 |
| CAS号 | 128-62-1 |
| 分子式 | C22H23NO7 |
| 分子量 | 413.42 |
| EINECS号 | 204-899-2 |
| 相关类别 | 镇咳药物;标准品;化工原料;医药原料药;Intermediates & Fine Chemicals;Pharmaceuticals;Asymmetric Synthesis;Chiral Building Blocks;Complex Molecules;FINACEAE |
| Mol文件 | 128-62-1.mol |
| 结构式 |  |
那可汀 性质
| 熔点 | 174-176 °C(lit.) |
|---|---|
| 比旋光度 | -200 º (c=1 in chloroform) |
| 沸点 | 532.6°C (rough estimate) |
| 密度 | 1.395 |
| 折射率 | 1.5614 (estimate) |
| 储存条件 | -20°C Freezer, Under Inert Atmosphere |
| 溶解度 | 几乎不溶于水，溶于丙酮，微溶于乙醇（96%）。溶于强酸；用水稀释溶液时，碱可能会沉淀。 |
| 酸度系数(pKa) | 7.8(at 25℃) |
| 形态 | Solid |
| 颜色 | 正交棱镜或粗针 |
| 旋光度 (Optical Rotation) | [α]20/D 200°, c = 1 in chloroform |
| 水溶解性 | 302.9mg/L(25 ºC) |
| Merck | 13,6752 |
| NIST化学物质信息 | Narcotine alkaloid(128-62-1) |
| EPA化学物质信息 | 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (128-62-1) |
Sigma opioid receptors Bradykinin Apoptosis
Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC
50
of 250 μM at 72 hours.
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.
Cell Viability Assay
| Cell Line: | Rat C6 glioma cells |
| Concentration: | 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM |
| Incubation Time: | 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours |
| Result: | Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. |
Noscapine (300 mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells |
| Dosage: | 300 mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume. |
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22 |
| 安全说明 | 24/25 |
| 危险品运输编号 | 1544 |
| WGK Germany | 3 |
| RTECS号 | RD2625000 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 海关编码 | 29329990 |
| 毒害物质数据 | 128-62-1(Hazardous Substances Data) |
| 毒性 | cyt-ham:lng 100 mg/L ATSUDG (4),41,80 |
| 提供商 | 语言 |
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英文
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