4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

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4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl manufacturers
4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Basic information
Product Name:4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Synonyms:4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;4-((3-Aminopropyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;4-[(3-aminopropyl)amino]-2-(2,6-dioxopiperidin-3- yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride;Thalidomide-NH-C4-NH2 HCl;Inhibitor,E3 Ligase Ligand-Linker Conjugates,inhibit,Pomalidomide C3 NH2 hydrochloride,Pomalidomide-C-3-NH2 hydrochloride,PomalidomideC3NH2 hydrochloride;Pomalidomide 4'-alkylC3-amine hydrochloride;Poma-C3-NH2·HCl;Pomalidomide-C3-amine HCl
CAS:2154342-45-5
MF:C16H19ClN4O4
MW:366.79946
EINECS:
Product Categories:
Mol File:2154342-45-5.mol
4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Structure
4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties
storage temp. Store at -20°C
form Solid
color Off-white to yellow
Safety Information
MSDS Information
4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Usage And Synthesis
UsesPomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
IC 50Cereblon
storageStore at -20°C
References[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials
Tag:4-[(3-Aminopropyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl(2154342-45-5) Related Product Information
4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Pomalidomide-C6-NH2?hydrochloride 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-((4-azidobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-C5-NH2 hydrochloride Pomalidomide 4'-alkylC5-acid Poma-C8-N3