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| | Pomalidomide 4'-alkylC5-acid Basic information |
| Product Name: | Pomalidomide 4'-alkylC5-acid | | Synonyms: | 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid;Pomalidomide-linker 3;-alkylC5-acid;6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoic acid;Thalidomide-NH-C5-COOH;6-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]hexanoic acid;Hexanoic acid, 6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-;Thalidomide-4-NH-C5-COOH | | CAS: | 2225940-49-6 | | MF: | C19H21N3O6 | | MW: | 387.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2225940-49-6.mol |  |
| | Pomalidomide 4'-alkylC5-acid Chemical Properties |
| Boiling point | 712.2±60.0 °C(Predicted) | | density | 1.443±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 4.75±0.10(Predicted) | | color | Light yellow to yellow |
| | Pomalidomide 4'-alkylC5-acid Usage And Synthesis |
| Description | Pomalidomide-C5-acid is an E3 ligase ligand-linker conjugate. | | Uses | Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC[1]. | | IC 50 | Cereblon | | storage | Store at -20°C | | References | [1] Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. Patent WO2018106870A1. |
| | Pomalidomide 4'-alkylC5-acid Preparation Products And Raw materials |
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