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Arimoclomol citrate

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Arimoclomol citrate Basic information
Product Name:Arimoclomol citrate
Synonyms:Arimoclomol citrate;BRX-220 citrate;(2R-)Arimoclomol citrate
CAS:368860-21-3
MF:C20H28ClN3O10
MW:505.91
EINECS:
Product Categories:
Mol File:368860-21-3.mol
Arimoclomol citrate Structure
Arimoclomol citrate Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
Arimoclomol citrate Usage And Synthesis
UsesArimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.
in vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

Animal Model:Male Wistar rats weighing 240 to 270 g[1]
Dosage:20 mg/kg
Administration:Administered intragastrically, for 5 days
Result:Had a protective effect against CCK-induced acute pancreatitis.
IC 50HSP
Arimoclomol citrate Preparation Products And Raw materials
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