| Company Name: |
ChemShuttle, Inc. |
| Tel: |
0510-83588313-811 18800520310 |
| Email: |
sales@chemshuttle.com |
6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid manufacturers
|
| | 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Basic information |
| Product Name: | 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid | | Synonyms: | 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid;VH 032-linker 5;(S,R. S)-AHPC-pentanoic-acid;VH 032 amide-alkylC4-acid;L-Prolinamide, N-(5-carboxy-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;6-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methyl-5-thiazolyl)benzyl]carbamoyl]-1-pyrrolidinyl]-3,3-dimethyl-1-oxo-2-butyl]amino]-6-oxohexanoic Acid;(S,R,S)-AHPC-C4-COOH;VH032-C3-COOH | | CAS: | 2172819-74-6 | | MF: | C28H38N4O6S | | MW: | 558.69 | | EINECS: | | | Product Categories: | | | Mol File: | 2172819-74-6.mol |  |
| | 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Chemical Properties |
| Boiling point | 878.5±65.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO, DMF | | pka | 4.70±0.10(Predicted) | | form | Solid | | color | white to light yellow | | InChIKey | DKSZOQIYZOVHOL-TYBLODHISA-N | | SMILES | C([C@@H](NC(CCCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1 |
| WGK Germany | WGK 3 | | HS Code | 2934100090 | | Storage Class | 11 - Combustible Solids |
| | 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Usage And Synthesis |
| Description | (S, R, S)-AHPC-pentanoic-acid is a PROTAC linker that incorporate an E3 ligase ligand with a linker to empower PROTAC drug research & discovery. It can react with amine containing molecules. | | Uses | (S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC[1]. | | storage | Store at -20°C | | References | [1] Liu Jing, et al. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. World Intellectual Property Organization, WO2020173440 A1 2020-09-03 |
| | 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Preparation Products And Raw materials |
|