VH 032 amide-alkylC2-acid manufacturers
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| | VH 032 amide-alkylC2-acid Basic information |
| Product Name: | VH 032 amide-alkylC2-acid | | Synonyms: | VH 032 amide-alkylC2-acid;4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid;(S,R,S)-AHPC-amido-C2-acid;(S,R,S)-AHPC-C2-COOH;VH032-C1-COOH;(S,R,S)-CO-C2-acid;3-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}propanoic acid;VH 032 anide-alky1C2-acid | | CAS: | 2172819-72-4 | | MF: | C26H34N4O6S | | MW: | 530.64 | | EINECS: | | | Product Categories: | PRORAC | | Mol File: | 2172819-72-4.mol |  |
| | VH 032 amide-alkylC2-acid Chemical Properties |
| Boiling point | 868.3±65.0 °C(Predicted) | | density | 1.306±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | methanol, ethyl acetate, DCM, THF, DMF, DMSO | | pka | 4.70±0.10(Predicted) | | form | Solid | | color | Off-white to light yellow | | Appearance | beige powder |
| | VH 032 amide-alkylC2-acid Usage And Synthesis |
| Description | (S,R,S)-AHPC-amido-C2-acid is a VHL ligand with a 2 carbon alkyl linker and terminal acid for PROTAC compounds. | | Uses | (S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands[1]. | | storage | Store at -20°C | | References | [1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912 |
| | VH 032 amide-alkylC2-acid Preparation Products And Raw materials |
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