5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE manufacturers
- SIBA
-
- $44.00 / 1mg
-
2026-03-13
- CAS:35899-54-8
- Min. Order:
- Purity: 99.48%
- Supply Ability: 10g
- SIBA
-
- $44.00 / 1mg
-
2026-03-13
- CAS:35899-54-8
- Min. Order:
- Purity: 99.48%
- Supply Ability: 10g
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| | 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Basic information |
| Product Name: | 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE | | Synonyms: | 5'-Isobutylthioadenosine;5'-ISOBUTYLTHIOADENOSINE;5'-DEOXY-5'-ISOBUTYLTHIOADENOSINE;5'-Deoxy-5'-isobutylthioadenosine;5’-deoxy-5’-s-isobutylthioadenosine;5'-S-(2-Methylpropyl)-5'-thioadenosine;SIBA;5'-S-Isobutyl-5'-deoxyadenosine;5'-S-Isobutylthioadenosine | | CAS: | 35899-54-8 | | MF: | C14H21N5O3S | | MW: | 339.41 | | EINECS: | | | Product Categories: | | | Mol File: | 35899-54-8.mol |  |
| | 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Chemical Properties |
| Boiling point | 631.2±65.0 °C(Predicted) | | density | 1.63±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | DMSO : ≥ 100 mg/mL (294.63 mM) | | form | Solid | | pka | 13.13±0.70(Predicted) | | color | Off-white to gray |
| | 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Usage And Synthesis |
| Uses | SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH.html" class="link-product" target="_blank">SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3]. | | in vivo | SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo[1].
SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo[1]. | Animal Model: | C57BL/6 female mice (4-8 weeks old)[1]. | | Dosage: | 150 mg/kg | | Administration: | Intraperitoneal injection; twice weekly for 3 weeks. | | Result: | Significantly reduced the median number of lung metastases. |
| Animal Model: | Adult syngeneic Wistar AG rats (8-week-old; subcutaneously grafted with RMS-J1 cells)[1]. | | Dosage: | 15 mg/kg | | Administration: | Intraperitoneal injection; thrice weekly for 4 weeks. | | Result: | Inhibited in vivo metastatic spread of RMS-J1 cells, and showed median numbers of lung metastatic nodules was 26. |
| | IC 50 | Plasmodium; HSV-1 | | References | [1] F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16. DOI:10.1007/BF01580402
[2] B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7. DOI:10.1128/JVI.22.1.160-167.1977
[3] Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9. DOI:10.1042/bj2040853 |
| | 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE Preparation Products And Raw materials |
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