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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- manufacturers

  • Zatolmilast
  • Zatolmilast pictures
  • $64.00
  • 2026-07-14
  • CAS:1606974-33-7
  • Purity: 99.31%
  • Supply Ability: 10g
  • Zatolmilast
  • Zatolmilast pictures
  • $64.00
  • 2026-07-14
  • CAS:1606974-33-7
  • Purity: 99.31%
  • Supply Ability: 10g
  • BPN14770
  • BPN14770 pictures
  • $1.00
  • 2025-09-01
  • CAS:1606974-33-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20T
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Basic information
Product Name:Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
Synonyms:Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-;Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit;2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid;Zatolmilast, 10 mM in DMSO;Zatolmilast (BPN14770);Zatolmilast (BPN14770) ，S6844;BPN14770;Zatolmilast
CAS:1606974-33-7
MF:C21H15ClF3NO2
MW:405.8
EINECS:
Product Categories:
Mol File:1606974-33-7.mol
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Structure
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Chemical Properties
Boiling point 514.4±50.0 °C(Predicted)
density 1.351±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 260 mg/mL (640.71 mM)
pka4.27±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Usage And Synthesis
UsesZatolmilast is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor for the treatment of fragile X syndrome and other brain disorders.
in vivo

Zatolmilast increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].
Zatolmilast (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].

Animal Model:C57Bl6 mice[2]
Dosage:0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:p.o.; 24hours
Result:Significantly improved novel object discrimination at doses above 0.3 mg/kg.
IC 50PDE4D3: 7.4 nM (IC50); PDE4D7: 7.8 nM (IC50)
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Preparation Products And Raw materials
Tag:Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-(1606974-33-7) Related Product Information
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- THPP-1 Bay 60-7550 PDE1-IN-1 (phosphate) 4-(azetidin-1-yl)-7-methyl-5-{1-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazine GSK-356278