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| | CHDI-390576 Basic information |
| Product Name: | CHDI-390576 | | Synonyms: | CHDI-390576;Benzeneacetamide, 2-fluoro-N-hydroxy-α-[4-[5-(trifluoromethyl)-2-pyrimidinyl]phenyl]-;CHDI390576,CHDI 390576;CID 81689842 | | CAS: | 1629729-98-1 | | MF: | C19H13F4N3O2 | | MW: | 391.32 | | EINECS: | | | Product Categories: | | | Mol File: | 1629729-98-1.mol |  |
| | CHDI-390576 Chemical Properties |
| density | 1.402±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (638.86 mM; Need ultrasonic) | | pka | 8.37±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | CHDI-390576 Usage And Synthesis |
| Uses | CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform[1]. | | IC 50 | HDAC4: 54 nM (IC50); HDAC5: 60 nM (IC50); HDAC7: 31 nM (IC50); hHDAC9: 50 nM (IC50); HDAC1: 39.7 μM (IC50); HDAC3: 25.8 μM (IC50); HDAC8: 9.1 μM (IC50); hHDAC6: 6.2 μM (IC50) | | storage | Store at -20°C | | References | [1] Luckhurst CA, et al. Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg Med Chem Lett. 2019 Jan 1;29(1):83-88. DOI:10.1016/j.bmcl.2018.11.009 |
| | CHDI-390576 Preparation Products And Raw materials |
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