| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
DPTIP manufacturers
- DPTIP
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- $41.00
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2026-07-14
- CAS:351353-48-5
- Purity: 99.88%
- Supply Ability: 10g
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| Product Name: | DPTIP | | Synonyms: | DPTIP;Phenol, 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]-;2,6-dimethoxy-4-[5-phenyl-4-(thiophen-2-yl)-1H-im
idazol-2-yl]phenol;extracellular,Inhibitor,exosome,DPTIP,Phospholipase,vesicles,inhibit,N-SMase;DPTIP, 10 mM in DMSO;2,6-Dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol;2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol | | CAS: | 351353-48-5 | | MF: | C21H18N2O3S | | MW: | 378.44 | | EINECS: | | | Product Categories: | | | Mol File: | 351353-48-5.mol |  |
| | DPTIP Chemical Properties |
| Boiling point | 608.3±55.0 °C(Predicted) | | density | 1.292±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.27±0.25(Predicted) | | form | Solid | | color | Off-white to gray |
| | DPTIP Usage And Synthesis |
| Uses | DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2]. | | in vivo | DPTIP potently (10mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release[1]. | Animal Model: | Mice[1]. | | Dosage: | 10mg/kg. | | Administration: | IP 0.5h prior to IL-1β striatal injection. | | Result: | Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4h after compound administration.
The number of astrocyte-derived EVs was reduced by 51±13% 2h post IL-1β administration.
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| | storage | Store at -20°C | | References | [1] Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. DOI:10.1038/s41598-018-36144-2
[2] Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. DOI:10.1080/14756366.2020.1754814 |
| | DPTIP Preparation Products And Raw materials |
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