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| | SNAP 94847 (hydrochloride) Basic information |
| Product Name: | SNAP 94847 (hydrochloride) | | Synonyms: | SNAP 94847 HCL;Antidepressant,SNAP-94847,Melanin concentrating hormone receptor 1,anxiety,inhibit,anxiolytic,SNAP 94847 hydrochloride,Inhibitor,SNAP 94847,SNAP94847,MCHR1 (GPR24);SNAP 94847 hydrochloride, 10 mM in DMSO;N-(3-(1-(4-(3,4-Difluorophenoxy)benzyl)piperidin-4-yl)-4-methylphenyl)isobutyramide hydrochloride;SNAP94847 hydrochloride ，S0080 | | CAS: | 1781934-47-1 | | MF: | C29H33ClF2N2O2 | | MW: | 515.04 | | EINECS: | | | Product Categories: | API | | Mol File: | 1781934-47-1.mol |  |
| | SNAP 94847 (hydrochloride) Chemical Properties |
| solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | | form | Solid | | color | White to light yellow |
| | SNAP 94847 (hydrochloride) Usage And Synthesis |
| Uses | SNAP 94847 Hydrochloride is an MCH1 antagonist. | | in vivo | SNAP 94847 hydrochloride (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals[2].
SNAP 94847 hydrochloride (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min[2].
SNAP 94847 hydrochloride (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study[3]. | Animal Model: | Rat[2] | | Dosage: | 20 mg/kg | | Administration: | Oral administration; 20 mg/kg; 14 days | | Result: | Exhibited a exaggerated locomotor response to acute quinpirole. |
| Animal Model: | Rat[2] | | Dosage: | 10 mg/kg | | Administration: | Oral administration; 10 mg/kg | | Result: | Exhibited good physicochemical properties in rats. |
| | storage | Desiccate at RT |
| | SNAP 94847 (hydrochloride) Preparation Products And Raw materials |
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