SALOR-INT L225193-1EA manufacturers
- ST-148
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- $2500.00
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2026-05-21
- CAS:400863-77-6
- Purity:
- Supply Ability: 10g
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| | SALOR-INT L225193-1EA Basic information |
| Product Name: | SALOR-INT L225193-1EA | | Synonyms: | SALOR-INT L225193-1EA;3-AMINO-N-(5-PHENYL-1,3,4-THIADIAZOL-2-YL)-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[B]THIENO[3,2-E]PYRIDINE-2-CARBOXAMIDE;3-amino-6,7,8,9-tetrahydro-5H-1-thia-10-azacyclohepta[f]indene-2-carboxylic acid (5-phenyl-[1,3,4]thiadiazol-2-yl)amide;5H-Cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide, 3-amino-6,7,8,9-tetrahydro-N-(5-phenyl-1,3,4-thiadiazol-2-yl)- | | CAS: | 400863-77-6 | | MF: | C21H19N5OS2 | | MW: | 421.54 | | EINECS: | | | Product Categories: | | | Mol File: | 400863-77-6.mol |  |
| | SALOR-INT L225193-1EA Chemical Properties |
| density | 1.437±0.06 g/cm3(Predicted) | | pka | 5.09±0.50(Predicted) |
| | SALOR-INT L225193-1EA Usage And Synthesis |
| Description | ST-148 is a potent Dengue virus capsid inhibitor. ST-148-enhanced capsid protein self-interaction perturbs assembly and disassembly of DV nucleocapsids, probably by inducing structural rigidity. | | Uses | ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle. | | References | [1] A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein |
| | SALOR-INT L225193-1EA Preparation Products And Raw materials |
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